Effect of one’s definition of bronchopulmonary dysplasia to your neurodevelopmental outcomes

Effect of one’s definition of bronchopulmonary dysplasia to your neurodevelopmental outcomes

Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24 +0 and < 32 +0 weeks gestation from were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.


Bronchopulmonary dysplasia (BPD) try a major effect in the really low beginning weight kids (VLBWIs). More serious BPD was from the an increased likelihood of developmental disability and you will shorter pulmonary means step one,2,3 . The medical course of the illness, such as the importance of rehospitalization and you may neurodevelopmental disability, was a documented concern certainly one of mothers and you will health care providers 4 . Understanding how situation seriousness try in the developmental delay and readmissions can help publication upcoming lookup and you may top quality improvement attempts to attenuate the duty in the infection.

BPD was laid out by the Northway et al. 5 over 50 years in the past; not, during the 2001, this new National Institute out-of Boy Health (NIH) modified the categorical significance out-of BPD. Now, inter-heart variability from inside the clean air government and you may nose cannula move, in addition to the access to noninvasive ventilation, is also bias the new NIH class from BPD visibility and seriousness. Put simply, such popular requirements may not be acceptable for the modern logical state or the forecast away from long-name ramifications of latest VLBWIs six,seven . According to this difference, Jensen ainsi que al. 8 proposed another type of definition of BPD you to definitely finest forecast very early youngsters morbidity and categorized situation severity depending on the form of breathing service, long lasting the means to access extra fresh air. That it meaning are revised so you’re able to significantly more accurately expect respiratory readmission and you may developmental waits for the a U.S.-born population.

And therefore, we aligned to choose hence definition of BPD from the an effective PMA regarding thirty six weeks is actually most suitable to possess predicting much time-identity neonatal effects, such as for instance pulmonary and neurologic consequences, measured in the 18–couple of years fixed age (CA), during the an excellent multicenter cohort examination of VLBWIs in line with the across the country Korean Neonatal System (KNN) amolatina desktop registry.

Overall performance

A total of 8294 children produced ranging from twenty four +0 days and you can 31 +6 days GA was in fact registered to the KNN, Shortly after excluding babies, 2889 VLBWIs stayed; one of them, 1849 (64.0%) got done follow-upwards suggestions offered by California 18–2 years, together with breathing readmission and you will developmental outcomes (Fig. 1). Of these 1849 VLBWIs, 1221 (66.0%) got BPD according to NIH definition, along with 665 children (36%) which have lightweight BPD, 184 infants (10%) having modest BPD, and you may 372 kids (19%) with significant BPD. In contrast 555 kids (30%) had BPD depending on the NRN meaning, along with 186 children (10%) having stages step 1 BPD, 303 children (16%) that have amount 2 BPD, and you will 66 infants (4%) that have amounts step three BPD (Desk step 1).

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